Galectin-12 (LGALS12)

About Galectin-12

Galectin-12 (LGALS12) is a protein from Homo sapiens identified by UniProt accession Q96DT0, 336 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.

Target properties

Protein name	Galectin-12
UniProt accession	Q96DT0
Gene	LGALS12
Organism	Homo sapiens
Length	336 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (39)

Diseases linked to this target (Open Targets).

hypertrophic cardiomyopathy · score 0.06
atherosclerosis · score 0.05
CIDEC-related familial partial lipodystrophy · score 0.05
obesity due to melanocortin 4 receptor deficiency · score 0.04
AKT2-related familial partial lipodystrophy · score 0.04
PPARG-related familial partial lipodystrophy · score 0.04
LIPE-related familial partial lipodystrophy · score 0.04
PLIN1-related familial partial lipodystrophy · score 0.04
familial partial lipodystrophy, Dunnigan type · score 0.04
mandibuloacral dysplasia · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96DT0-F1	alphafold	PREDICTED	88.57	—

Amino-acid sequence (336 residues)

MSQPSGGRAP GTRIYSWSCP TVMSPGEKLD PIPDSFILQP PVFHPVVPYV TTIFGGLHAG KMVMLQGVVP LDAHRFQVDF QCGCSLCPRP DIAFHFNPRF HTTKPHVICN TLHGGRWQRE ARWPHLALRR GSSFLILFLF GNEEVKVSVN GQHFLHFRYR LPLSHVDTLG IFGDILVEAV GFLNINPFVE GSREYPAGHP FLLMSPRLEV PCSHALPQGL SPGQVIIVRG LVLQEPKHFT VSLRDQAAHA PVTLRASFAD RTLAWISRWG QKKLISAPFL FYPQRFFEVL LLFQEGGLKL ALNGQGLGAT SMNQQALEQL RELRISGSVQ LYCVHS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards