About Mdm2-binding protein
Mdm2-binding protein (MTBP) is a protein
from Homo sapiens identified by UniProt accession
Q96DY7, 904 residues long.
MolForge cross-references it against 0 known binders and
48 disease associations.
Target properties
| Protein name | Mdm2-binding protein |
|---|
| UniProt accession | Q96DY7 |
|---|
| Gene | MTBP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 904 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (48)
Diseases linked to this target (Open Targets).
- pathological myopia · score 0.14
- optic cup area measurement · score 0.11
- prostate carcinoma · score 0.11
- prostate cancer · score 0.11
- Familial prostate cancer · score 0.11
- hepatocellular carcinoma · score 0.10
- body height · score 0.10
- BMI-adjusted waist-hip ratio · score 0.10
- refractive error · score 0.09
- Abnormality of refraction · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96DY7-F1 | alphafold | PREDICTED | 63.43 | — |
Amino-acid sequence (904 residues)
MDRYLLLVIW GEGKFPSAAS REAEHGPEVS SGEGTENQPD FTAANVYHLL KRSISASINP EDSTFPACSV GGIPGSKKWF FAVQAIYGFY QFCSSDWQEI HFDTEKDKIE DVLQTNIEEC LGAVECFEEE DSNSRESLSL ADLYEEAAEN LHQLSDKLPA PGRAMVDIIL LLSDKDPPKL KDYLPTVGAL KHLREWYSAK ITIAGNHCEI NCQKIAEYLS ANVVSLEDLR NVIDSKELWR GKIQIWERKF GFEISFPEFC LKGVTLKNFS TSNLNTDFLA KKIIPSKDKN ILPKVFHYYG PALEFVQMIK LSDLPSCYMS DIEFELGLTN STKQNSVLLL EQISSLCSKV GALFVLPCTI SNILIPPPNQ LSSRKWKEYI AKKPKTISVP DVEVKGECSS YYLLLQGNGN RRCKATLIHS ANQINGSFAL NLIHGKMKTK TEEAKLSFPF DLLSLPHFSG EQIVQREKQL ANVQVLALEE CLKRRKLAKQ PETVSVAELK SLLVLTRKHF LDYFDAVIPK MILRKMDKIK TFNILNDFSP VEPNSSSLME TNPLEWPERH VLQNLETFEK TKQKMRTGSL PHSSEQLLGH KEGPRDSITL LDAKELLKYF TSDGLPIGDL QPLPIQKGEK TFVLTPELSP GKLQVLPFEK ASVCHYHGIE YCLDDRKALE RDGGFSELQS RLIRYETQTT CTRESFPVPT VLSPLPSPVV SSDPGSVPDG EVLQNELRTE VSRLKRRSKD LNCLYPRKRL VKSESSESLL SQTTGNSNHY HHHVTSRKPQ TERSLPVTCP LVPIPSCETP KLATKTSSGQ KSMHESKTSR QIKESRSQKH TRILKEVVTE TLKKHSITET HECFTACSQR LFEISKFYLK DLKTSRGLFE EMKKTANNNA VQVIDWVLEK TSKK
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