Arylsulfatase G (ARSG)

About Arylsulfatase G

Arylsulfatase G (ARSG) is a protein from Homo sapiens identified by UniProt accession Q96EG1, 525 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.

Target properties

Protein name	Arylsulfatase G
UniProt accession	Q96EG1
Gene	ARSG
Organism	Homo sapiens
Length	525 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (52)

Diseases linked to this target (Open Targets).

Usher syndrome · score 0.62
neurodegenerative disease · score 0.41
Usher syndrome type 3 · score 0.37
body height · score 0.28
chloride measurement · score 0.26
sodium measurement · score 0.26
hemoglobin A1 measurement · score 0.22
mean corpuscular hemoglobin concentration · score 0.22
Limb dystonia · score 0.21
low density lipoprotein cholesterol measurement · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96EG1-F1	alphafold	PREDICTED	91.81	—

Amino-acid sequence (525 residues)

MGWLFLKVLL AGVSFSGFLY PLVDFCISGK TRGQKPNFVI ILADDMGWGD LGANWAETKD TANLDKMASE GMRFVDFHAA ASTCSPSRAS LLTGRLGLRN GVTRNFAVTS VGGLPLNETT LAEVLQQAGY VTGIIGKWHL GHHGSYHPNF RGFDYYFGIP YSHDMGCTDT PGYNHPPCPA CPQGDGPSRN LQRDCYTDVA LPLYENLNIV EQPVNLSSLA QKYAEKATQF IQRASTSGRP FLLYVALAHM HVPLPVTQLP AAPRGRSLYG AGLWEMDSLV GQIKDKVDHT VKENTFLWFT GDNGPWAQKC ELAGSVGPFT GFWQTRQGGS PAKQTTWEGG HRVPALAYWP GRVPVNVTST ALLSVLDIFP TVVALAQASL PQGRRFDGVD VSEVLFGRSQ PGHRVLFHPN SGAAGEFGAL QTVRLERYKA FYITGGARAC DGSTGPELQH KFPLIFNLED DTAEAVPLER GGAEYQAVLP EVRKVLADVL QDIANDNISS ADYTQDPSVT PCCNPYQIAC RCQAA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards