E3 ubiquitin-protein ligase NEURL3 (NEURL3)

About E3 ubiquitin-protein ligase NEURL3

E3 ubiquitin-protein ligase NEURL3 (NEURL3) is a protein from Homo sapiens identified by UniProt accession Q96EH8, 262 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase NEURL3
UniProt accession	Q96EH8
Gene	NEURL3
Organism	Homo sapiens
Length	262 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (29)

Diseases linked to this target (Open Targets).

eosinophil count · score 0.32
pulse pressure measurement · score 0.27
lymphocyte:monocyte ratio · score 0.07
lymphocyte percentage of leukocytes · score 0.07
sex hormone-binding globulin measurement · score 0.07
eosinophil percentage of granulocytes · score 0.06
BMI-adjusted hip circumference · score 0.06
sum of eosinophil and basophil counts · score 0.04
neutrophil percentage of granulocytes · score 0.03
mean platelet volume · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96EH8-F1	alphafold	PREDICTED	81.13	—

Amino-acid sequence (262 residues)

MGAQLCFEAN AKAPREALRF HAEAKGAQVR LDTRGCIAHR RTTFHDGIVF SQRPVRLGER VALRVLREES GWCGGLRVGF TRLDPACVSV PSLPPFLCPD LEEQSPTWAA VLPEGCALTG DLVRFWVDRR GCLFAKVNAG CRLLLREGVP VGAPLWAVMD VYGTTKAIEL LDPTASRLPT PMPWDLSNKA VPEPKATPGE ECAICFYHAA NTRLVPCGHT YFCRYCAWRV FSDTAKCPVC RWQIEAVAPA QGPPALRVEE GS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards