WD repeat-containing protein 89 (WDR89)

About WD repeat-containing protein 89

WD repeat-containing protein 89 (WDR89) is a protein from Homo sapiens identified by UniProt accession Q96FK6, 387 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.

Target properties

Protein name	WD repeat-containing protein 89
UniProt accession	Q96FK6
Gene	WDR89
Organism	Homo sapiens
Length	387 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (10)

Diseases linked to this target (Open Targets).

sphingomyelin measurement · score 0.28
neurodegenerative disease · score 0.06
ptosis · score 0.04
histidinemia · score 0.04
hypouricemia, renal, 2 · score 0.03
allergic rhinitis · score 0.02
acrocephalopolysyndactyly · score 0.01
cancer · score 0.00
COVID-19 · score 0.00
neoplasm · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96FK6-F1	alphafold	PREDICTED	87.68	—

Amino-acid sequence (387 residues)

MEKIEEQFAN LHIVKCSLGT KEPTYLLGID TSKTVQAGKE NLVAVLCSNG SIRIYDKERL NVLREFSGYP GLLNGVRFAN SCDSVYSACT DGTVKCWDAR VAREKPVQLF KGYPSNIFIS FDINCNDHII CAGTEKVDDD ALLVFWDARM NSQNLSTTKD SLGAYSETHS DDVTQVRFHP SNPNMVVSGS SDGLVNVFDI NIDNEEDALV TTCNSISSVS CIGWSGKGYK QIYCMTHDEG FYWWDLNHLD TDEPVTRLNI QDVREVVNMK EDALDYLIGG LYHEKTDTLH VIGGTNKGRI HLMNCSMSGL THVTSLQGGH AATVRSFCWN VQDDSLLTGG EDAQLLLWKP GAIEKTFTKK ESMKIASSVH QRVRVHSNDS YKRRKKQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards