Melanocortin-2 receptor accessory protein 2 (MRAP2)

About Melanocortin-2 receptor accessory protein 2

Melanocortin-2 receptor accessory protein 2 (MRAP2) is a protein from Homo sapiens identified by UniProt accession Q96G30, 205 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.

Target properties

Protein name	Melanocortin-2 receptor accessory protein 2
UniProt accession	Q96G30
Gene	MRAP2
Organism	Homo sapiens
Length	205 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (71)

Diseases linked to this target (Open Targets).

obesity · score 0.38
inherited obesity · score 0.37
body mass index · score 0.22
obesity due to melanocortin 4 receptor deficiency · score 0.20
MODY · score 0.07
Obesity · score 0.06
obesity due to pro-opiomelanocortin deficiency · score 0.05
dysplasia epiphysealis hemimelica · score 0.05
obesity due to prohormone convertase I deficiency · score 0.05
obesity due to congenital leptin deficiency · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96G30-F1	alphafold	PREDICTED	57.09	—

Amino-acid sequence (205 residues)

MSAQRLISNR TSQQSASNSD YTWEYEYYEI GPVSFEGLKA HKYSIVIGFW VGLAVFVIFM FFVLTLLTKT GAPHQDNAES SEKRFRMNSF VSDFGRPLEP DKVFSRQGNE ESRSLFHCYI NEVERLDRAK ACHQTTALDS DVQLQEAIRS SGQPEEELNR LMKFDIPNFV NTDQNYFGED DLLISEPPIV LETKPLSQTS HKDLD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards