Diphosphoinositol polyphosphate phosphohydrolase…

About Diphosphoinositol polyphosphate phosphohydrolase 3-beta

Diphosphoinositol polyphosphate phosphohydrolase 3-beta (NUDT11) is a protein from Homo sapiens identified by UniProt accession Q96G61, 164 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.

Target properties

Protein name	Diphosphoinositol polyphosphate phosphohydrolase 3-beta
UniProt accession	Q96G61
Gene	NUDT11
Organism	Homo sapiens
Length	164 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (28)

Diseases linked to this target (Open Targets).

male reproductive organ cancer · score 0.29
prostate carcinoma · score 0.23
prostate cancer · score 0.23
pancreatic adenocarcinoma · score 0.04
neoplasm · score 0.01
colorectal cancer · score 0.01
cancer · score 0.01
laryngeal squamous cell carcinoma · score 0.01
bladder transitional cell carcinoma · score 0.01
endometrial carcinoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96G61-F1	alphafold	PREDICTED	88.50	—

Amino-acid sequence (164 residues)

MKCKPNQTRT YDPEGFKKRA ACLCFRSERE DEVLLVSSSR YPDRWIVPGG GMEPEEEPGG AAVREVYEEA GVKGKLGRLL GVFEQNQDRK HRTYVYVLTV TELLEDWEDS VSIGRKREWF KVEDAIKVLQ CHKPVHAEYL EKLKLGGSPT NGNSMAPSSP DSDP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Diphosphoinositol polyphosphate phosphohydrolase 3-beta (NUDT11)