About Transmembrane protein 169
Transmembrane protein 169 (TMEM169) is a protein
from Homo sapiens identified by UniProt accession
Q96HH4, 297 residues long.
MolForge cross-references it against 0 known binders and
9 disease associations.
Target properties
| Protein name | Transmembrane protein 169 |
|---|
| UniProt accession | Q96HH4 |
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| Gene | TMEM169 |
|---|
| Organism | Homo sapiens |
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| Length | 297 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (9)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.51
- age at menopause · score 0.14
- vital capacity · score 0.09
- forced expiratory volume · score 0.07
- heel bone mineral density · score 0.04
- protein measurement · score 0.03
- body height · score 0.02
- Ataxia-telangiectasia · score 0.02
- secondary progressive multiple sclerosis · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96HH4-F1 | alphafold | PREDICTED | 54.60 | — |
Amino-acid sequence (297 residues)
MEEPTAVEGQ VQLPSPHQGS LRKAVAAALA LDGESTMGHR KKKRKESRPE SIIIYRSDNE KTDEEPGESE GGDQPKEEEG DDFLDYPVDD DMWNLPLDSR YVTLTGTITR GKKKGQMVDI HVTLTEKELQ ELTKPKESSR ETTPEGRMAC QMGADRGPHV VLWTLICLPV VFILSFVVSF YYGTITWYNI FLVYNEERTF WHKISYCPCL VLFYPVLIMA MASSLGLYAA VVQLSWSWEA WWQAARDMEK GFCGWLCSKL GLEDCSPYSI VELLESDNIS STLSNKDPIQ EVETSTV
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