About Adenosylhomocysteinase 3
Adenosylhomocysteinase 3 (AHCYL2) is a protein
from Homo sapiens identified by UniProt accession
Q96HN2, 611 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Adenosylhomocysteinase 3 |
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| UniProt accession | Q96HN2 |
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| Gene | AHCYL2 |
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| Organism | Homo sapiens |
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| Length | 611 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (35)
Diseases linked to this target (Open Targets).
- hemoglobin measurement · score 0.35
- hematocrit · score 0.28
- neurodegenerative disease · score 0.26
- response to fenofibrate · score 0.24
- cutaneous melanoma · score 0.11
- blood protein measurement · score 0.08
- mean platelet volume · score 0.03
- metabolite measurement · score 0.03
- colorectal cancer · score 0.03
- gonorrhea · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96HN2-F1 | alphafold | PREDICTED | 79.18 | — |
Amino-acid sequence (611 residues)
MSVQVVSAAA AAKVPEVELK DLSPSEAESQ LGLSTAAVGA MAPPAGGGDP EAPAPAAERP PVPGPGSGPA AALSPAAGKV PQASAMKRSD PHHQHQRHRD GGEALVSPDG TVTEAPRTVK KQIQFADQKQ EFNKRPTKIG RRSLSRSISQ SSTDSYSSAA SYTDSSDDET SPRDKQQKNS KGSSDFCVKN IKQAEFGRRE IEIAEQEMPA LMALRKRAQG EKPLAGAKIV GCTHITAQTA VLMETLGALG AQCRWAACNI YSTLNEVAAA LAESGFPVFA WKGESEDDFW WCIDRCVNVE GWQPNMILDD GGDLTHWIYK KYPNMFKKIK GIVEESVTGV HRLYQLSKAG KLCVPAMNVN DSVTKQKFDN LYCCRESILD GLKRTTDMMF GGKQVVVCGY GEVGKGCCAA LKAMGSIVYV TEIDPICALQ ACMDGFRLVK LNEVIRQVDI VITCTGNKNV VTREHLDRMK NSCIVCNMGH SNTEIDVASL RTPELTWERV RSQVDHVIWP DGKRIVLLAE GRLLNLSCST VPTFVLSITA TTQALALIEL YNAPEGRYKQ DVYLLPKKMD EYVASLHLPT FDAHLTELTD EQAKYLGLNK NGPFKPNYYR Y
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