About H/ACA ribonucleoprotein complex non-core subunit NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1 (NAF1) is a protein
from Homo sapiens identified by UniProt accession
Q96HR8, 494 residues long.
MolForge cross-references it against 0 known binders and
15 disease associations.
Target properties
| Protein name | H/ACA ribonucleoprotein complex non-core subunit NAF1 |
|---|
| UniProt accession | Q96HR8 |
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| Gene | NAF1 |
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| Organism | Homo sapiens |
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| Length | 494 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (15)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 7 · score 0.51
- dyskeratosis congenita · score 0.46
- pulmonary fibrosis · score 0.39
- telomere length · score 0.38
- protein measurement · score 0.26
- lysosomal storage disease · score 0.23
- TPE interval measurement · score 0.15
- response to exercise · score 0.15
- self reported educational attainment · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96HR8-F1 | alphafold | PREDICTED | 61.22 | — |
Amino-acid sequence (494 residues)
MEVVEAAAAQ LETLKFNGTD FGVGEGPAAP SPGSAPVPGT QPPLQSFEGS PDAGQTVEVK PAGEQPLQPV LNAVAAGTPA PQPQPPAESP ACGDCVTSPG AAEPARAPDS LETSDSDSDS DSETDSDSSS SSSSSSSSSS SSSSSCISLP PVLSDGDDDL QIEKENKNFP LKTKDELLLN ELPSVEELTI ILPEDIELKP LGMVSSIIEQ LVIIESMTNL PPVNEETVIF KSDRQAAGKI FEIFGPVAHP FYVLRFNSSD HIESKGIKIK ETMYFAPSMK DFTQYIFTEK LKQDKGSDAS WKNDQEPPPE ALDFSDDEKE KEAKQRKKSQ IQGRKKLKSE FNEPGEDFTE VHQNWNAHSS ASEHAKGYRN REFTRGFSRA RYPRSCHGRP PPQHFYNSEH MVSQETSGFP SQRQNNPIMP QYPFPLPVFD MHNFPLRPPP PPPPPPVNMG WATPNMAAHP LLNLPYSLPP PPPPPPLPPP PSSGDSNSHF GPYY
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