Selenocysteine lyase (SCLY)

About Selenocysteine lyase

Selenocysteine lyase (SCLY) is a protein from Homo sapiens identified by UniProt accession Q96I15, 445 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.

Target properties

Protein name	Selenocysteine lyase
UniProt accession	Q96I15
Gene	SCLY
Organism	Homo sapiens
Length	445 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (47)

Diseases linked to this target (Open Targets).

Alzheimer disease · score 0.31
lysosomal storage disease · score 0.31
Parkinson disease · score 0.31
neurodegenerative disease · score 0.31
multiple sclerosis · score 0.31
creatinine measurement · score 0.27
protein measurement · score 0.25
mathematical ability · score 0.24
eosinophil count · score 0.15
appendicular lean mass · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96I15-F1	alphafold	PREDICTED	90.40	—

Amino-acid sequence (445 residues)

MEAAVAPGRD APAPAASQPS GCGKHNSPER KVYMDYNATT PLEPEVIQAM TKAMWEAWGN PSSPYSAGRK AKDIINAARE SLAKMIGGKP QDIIFTSGGT ESNNLVIHSV VKHFHANQTS KGHTGGHHSP VKGAKPHFIT SSVEHDSIRL PLEHLVEEQV AAVTFVPVSK VSGQAEVDDI LAAVRPTTRL VTIMLANNET GIVMPVPEIS QRIKALNQER VAAGLPPILV HTDAAQALGK QRVDVEDLGV DFLTIVGHKF YGPRIGALYI RGLGEFTPLY PMLFGGGQER NFRPGTENTP MIAGLGKAAE LVTQNCEAYE AHMRDVRDYL EERLEAEFGQ KRIHLNSQFP GTQRLPNTCN FSIRGPRLQG HVVLAQCRVL MASVGAACHS DHGDQPSPVL LSYGVPFDVA RNALRLSVGR STTRAEVDLV VQDLKQAVAQ LEDQA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards