Germ cell-less protein-like 1 (GMCL1)

About Germ cell-less protein-like 1

Germ cell-less protein-like 1 (GMCL1) is a protein from Homo sapiens identified by UniProt accession Q96IK5, 515 residues long. MolForge cross-references it against 0 known binders and 119 disease associations.

Target properties

Protein name	Germ cell-less protein-like 1
UniProt accession	Q96IK5
Gene	GMCL1
Organism	Homo sapiens
Length	515 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (119)

Diseases linked to this target (Open Targets).

platelet count · score 0.42
Red cell distribution width · score 0.37
mean platelet volume · score 0.32
reticulocyte count · score 0.28
chronotype measurement · score 0.26
atrial fibrillation · score 0.25
platelet crit · score 0.23
reticulocyte measurement · score 0.22
azoospermia · score 0.10
male infertility with teratozoospermia due to single gene mutation · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96IK5-F1	alphafold	PREDICTED	84.18	—

Amino-acid sequence (515 residues)

MGSLSSRVLR QPRPALAQQA QGARAGGSAR RPDTGDDAAG HGFCYCAGSH KRKRSSGSFC YCHPDSETDE DEEEGDEQQR LLNTPRRKKL KSTSKYIYQT LFLNGENSDI KICALGEEWS LHKIYLCQSG YFSSMFSGSW KESSMNIIEL EIPDQNIDVE ALQVAFGSLY RDDVLIKPSR VVAILAAACL LQLDGLIQQC GETMKETVNV KTVCGYYTSA GTYGLDSVKK KCLEWLLNNL MTHQNVELFK ELSINVMKQL IGSSNLFVMQ VEMDIYTALK KWMFLQLVPS WNGSLKQLLT ETDVWFSKQR KDFEGMAFLE TEQGKPFVSV FRHLRLQYII SDLASARIIE QDAVVPSEWL SSVYKQQWFA MLRAEQDSEV GPQEINKEEL EGNSMRCGRK LAKDGEYCWR WTGFNFGFDL LVTYTNRYII FKRNTLNQPC SGSVSLQPRR SIAFRLRLAS FDSSGKLICS RTTGYQILTL EKDQEQVVMN LDSRLLIFPL YICCNFLYIS PEKKN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards