About Zinc finger protein 496
Zinc finger protein 496 (ZNF496) is a protein
from Homo sapiens identified by UniProt accession
Q96IT1, 587 residues long.
MolForge cross-references it against 0 known binders and
40 disease associations.
Target properties
| Protein name | Zinc finger protein 496 |
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| UniProt accession | Q96IT1 |
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| Gene | ZNF496 |
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| Organism | Homo sapiens |
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| Length | 587 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (40)
Diseases linked to this target (Open Targets).
- monocyte percentage of leukocytes · score 0.32
- platelet component distribution width · score 0.29
- monocyte count · score 0.24
- mean corpuscular hemoglobin · score 0.19
- granulocyte percentage of myeloid white cells · score 0.13
- C-reactive protein measurement · score 0.10
- beta-thalassemia-X-linked thrombocytopenia syndrome · score 0.05
- macrothrombocytopenia, isolated, 2, autosomal dominant · score 0.05
- thrombocytopenia 4 · score 0.05
- congenital amegakaryocytic thrombocytopenia 1 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96IT1-F1 | alphafold | PREDICTED | 54.32 | — |
Amino-acid sequence (587 residues)
MPTALCPRVL APKESEEPRK MRSPPGENPS PQGELPSPES SRRLFRRFRY QEAAGPREAL QRLWDLCGGW LRPERHTKEQ ILELLVLEQF LAILPREIQS WVRAQEPESG EQAVAAVEAL EREPGRPWQW LKHCEDPVVI DDGDSPLDQE QEQLPVEPHS DLAKNQDAQP ITLAQCLGLP SRPPSQLSGD PVLQDAFLLQ EENVRDTQQV TTLQLPPSRV SPFKDMILCF SEEDWSLLDP AQTGFYGEFI IGEDYGVSMP PNDLAAQPDL SQGEENEPRV PELQDLQGKE VPQVSYLDSP SLQPFQVEER RKREELQVPE FQACPQTVVP QNTYPAGGNP RSLENSLDEE VTIEIVLSSS GDEDSQHGPY CTEELGSPTE KQRSLPASHR SSTEAGGEVQ TSKKSYVCPN CGKIFRWRVN FIRHLRSRRE QEKPHECSVC GELFSDSEDL DGHLESHEAQ KPYRCGACGK SFRLNSHLLS HRRIHLQPDR LQPVEKREQA ASEDADKGPK EPLENGKAKL SFQCCECGKA FQRHDHLARH RSHFHLKDKA RPFQCRYCVK SFTQNYDLLR HERLHMKRRS KQALNSY
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