PRKC apoptosis WT1 regulator protein (PAWR)

About PRKC apoptosis WT1 regulator protein

PRKC apoptosis WT1 regulator protein (PAWR) is a protein from Homo sapiens identified by UniProt accession Q96IZ0, 340 residues long. MolForge cross-references it against 0 known binders and 141 disease associations.

Target properties

Protein name	PRKC apoptosis WT1 regulator protein
UniProt accession	Q96IZ0
Gene	PAWR
Organism	Homo sapiens
Length	340 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (141)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
cortical surface area measurement · score 0.40
leukocyte count · score 0.40
neuroimaging measurement · score 0.39
neutrophil count · score 0.39
cortical thickness · score 0.39
brain measurement · score 0.36
pulse pressure measurement · score 0.35
myeloid white cell count · score 0.35
peripheral arterial disease · score 0.35

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96IZ0-F1	alphafold	PREDICTED	63.73	—

Amino-acid sequence (340 residues)

MATGGYRTSS GLGGSTTDFL EEWKAKREKM RAKQNPPGPA PPGGGSSDAA GKPPAGALGT PAAAAANELN NNLPGGAPAA PAVPGPGGVN CAVGSAMLTR AAPGPRRSED EPPAASASAA PPPQRDEEEP DGVPEKGKSS GPSARKGKGQ IEKRKLREKR RSTGVVNIPA AECLDEYEDD EAGQKERKRE DAITQQNTIQ NEAVNLLDPG SSYLLQEPPR TVSGRYKSTT SVSEEDVSSR YSRTDRSGFP RYNRDANVSG TLVSSSTLEK KIEDLEKEVV RERQENLRLV RLMQDKEEMI GKLKEEIDLL NRDLDDIEDE NEQLKQENKT LLKVVGQLTR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards