tRNA N(3)-cytidine methyltransferase METTL2A (METTL2A)

About tRNA N(3)-cytidine methyltransferase METTL2A

tRNA N(3)-cytidine methyltransferase METTL2A (METTL2A) is a protein from Homo sapiens identified by UniProt accession Q96IZ6, 378 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.

Target properties

Protein name	tRNA N(3)-cytidine methyltransferase METTL2A
UniProt accession	Q96IZ6
Gene	METTL2A
Organism	Homo sapiens
Length	378 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (19)

Diseases linked to this target (Open Targets).

body height · score 0.28
hypothyroidism · score 0.13
genetic disorder · score 0.12
heel bone mineral density · score 0.04
mathematical ability · score 0.03
mean corpuscular volume · score 0.03
cancer · score 0.03
cystatin C measurement · score 0.02
neoplasm · score 0.02
Invasive Breast Carcinoma · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96IZ6-F1	alphafold	PREDICTED	81.84	—

Amino-acid sequence (378 residues)

MAGSYPEGAP AVLADKRQQF GSRFLRDPAR VFHHNAWDNV EWSEEQAAAA ERKVQENSIQ RVCQEKQVDY EINAHKYWND FYKIHENGFF KDRHWLFTEF PELAPSQNQN HLKDWFLENK SEVPECRNNE DGPGLIMEEQ HKCSSKSLEH KTQTLPVEEN VTQKISDLEI CADEFPGSSA TYRILEVGCG VGNTVFPILQ TNNDPGLFVY CCDFSSTAIE LVQTNSEYDP SRCFAFVHDL CDEEKSYPVP KGSLDIIILI FVLSAIVPDK MQKAINRLSR LLKPGGMMLL RDYGRYDMAQ LRFKKGQCLS GNFYVRGDGT RVYFFTQEEL DTLFTTAGLE KVQNLVDRRL QVNRGKQLTM YRVWIQCKYC KPLLSSTS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards