Thioredoxin domain-containing protein 15 (TXNDC15)

About Thioredoxin domain-containing protein 15

Thioredoxin domain-containing protein 15 (TXNDC15) is a protein from Homo sapiens identified by UniProt accession Q96J42, 360 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.

Target properties

Protein name	Thioredoxin domain-containing protein 15
UniProt accession	Q96J42
Gene	TXNDC15
Organism	Homo sapiens
Length	360 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (42)

Diseases linked to this target (Open Targets).

Meckel syndrome · score 0.70
meckel syndrome 14 · score 0.64
Mungan syndrome · score 0.54
neurodegenerative disease · score 0.31
genetic disorder · score 0.19
blood protein measurement · score 0.13
severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive · score 0.12
Menkes disease · score 0.03
ovarian carcinoma · score 0.02
visceral Leishmaniasis · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96J42-F1	alphafold	PREDICTED	64.22	—

Amino-acid sequence (360 residues)

MVPAAGRRPP RVMRLLGWWQ VLLWVLGLPV RGVEVAEESG RLWSEEQPAH PLQVGAVYLG EEELLHDPMG QDRAAEEANA VLGLDTQGDH MVMLSVIPGE AEDKVSSEPS GVTCGAGGAE DSRCNVRESL FSLDGAGAHF PDREEEYYTE PEVAESDAAP TEDSNNTESL KSPKVNCEER NITGLENFTL KILNMSQDLM DFLNPNGSDC TLVLFYTPWC RFSASLAPHF NSLPRAFPAL HFLALDASQH SSLSTRFGTV AVPNILLFQG AKPMARFNHT DRTLETLKIF IFNQTGIEAK KNVVVTQADQ IGPLPSTLIK SVDWLLVFSL FFLISFIMYA TIRTESIRWL IPGQEQEHVE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards