About Membrane-spanning 4-domains subfamily A member 14
Membrane-spanning 4-domains subfamily A member 14 (MS4A14) is a protein
from Homo sapiens identified by UniProt accession
Q96JA4, 679 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | Membrane-spanning 4-domains subfamily A member 14 |
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| UniProt accession | Q96JA4 |
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| Gene | MS4A14 |
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| Organism | Homo sapiens |
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| Length | 679 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (27)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.33
- blood protein measurement · score 0.25
- cystatin C measurement · score 0.23
- HbA1c measurement · score 0.18
- ferritin measurement · score 0.17
- essential tremor · score 0.11
- platelet count · score 0.08
- monocyte percentage of leukocytes · score 0.08
- neutrophil percentage of leukocytes · score 0.02
- Acute hepatic failure · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96JA4-F1 | alphafold | PREDICTED | 48.33 | — |
Amino-acid sequence (679 residues)
MESTSQDRRA THVITIKPNE TVLTAFPYRP HSSLLDFLKG EPRVLGATQI LLALIIVGFG TIFALNYIGF SQRLPLVVLT GYPFWGALIF ILTGYLTVTD KKSKLLGQGV TGMNVISSLV AITGITFTIL SYRHQDKYCQ MPSFEEICVF SRTLFIVLFF LPSDVTQNSE QPAPEENDQL QFVLQEEFSS DDSTTNAQSV IFGGYAFFKL TLSRSPLVSQ PGNKGREFVP DEQKQSILPS PKFSEEEIEP LPPTLEKKPS ENMSIQLDST FKQMKDEDLQ SAIVQPSQMQ TKLLQDQAAS LQVFPSHSAL KLEDISPEDL PSQALPVEGL SEQTMPSKST SSHVKQSSNL TANDLPPQGI LSQDTSSQDM LFHDMTSQDM QSLDMLSQDT PSHAMPPQDI PSQDMLSQAL SAHAILPEAS TSHIVQFPEI QHLLQQPPDL QPENTEPQNQ QILQMSYQDI RSEVMEETKE WKSEEELHRR KSSRRHSLNQ QTKALQYLRR HSLDVQAKGQ KSSKRHSLDQ QSKGWQSPKQ KSLDQQIKDW LSPKRHSVDK QAQLNQTKEQ LPDQQAEDQQ AKGEQYPEGQ SKDGQVKDQQ TDKEQNSKKQ TQDQQTEDQP AQEKKSPKGQ FQNVQAEGQQ AQVEKVPKLL CQDSESQIQQ YQFWQFHKGN LQAGQPRTVN LLAKNPLTG
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