About E3 ubiquitin-protein ligase ZFP91
E3 ubiquitin-protein ligase ZFP91 (ZFP91) is a protein
from Homo sapiens identified by UniProt accession
Q96JP5, 570 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase ZFP91 |
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| UniProt accession | Q96JP5 |
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| Gene | ZFP91 |
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| Organism | Homo sapiens |
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| Length | 570 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (71)
Diseases linked to this target (Open Targets).
- serum gamma-glutamyl transferase measurement · score 0.38
- systolic blood pressure · score 0.33
- chronotype measurement · score 0.31
- Agents acting on the renin-angiotensin system use measurement · score 0.29
- body height · score 0.26
- HMG CoA reductase inhibitor use measurement · score 0.25
- cardiovascular disease · score 0.24
- Calcium channel blocker use measurement · score 0.24
- Hypercholesterolemia · score 0.22
- pulse pressure measurement · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96JP5-F1 | alphafold | PREDICTED | 51.62 | — |
Amino-acid sequence (570 residues)
MPGETEEPRP PEQQDQEGGE AAKAAPEEPQ QRPPEAVAAA PAGTTSSRVL RGGRDRGRAA AAAAAAAVSR RRKAEYPRRR RSSPSARPPD VPGQQPQAAK SPSPVQGKKS PRLLCIEKVT TDKDPKEEKE EEDDSALPQE VSIAASRPSR GWRSSRTSVS RHRDTENTRS SRSKTGSLQL ICKSEPNTDQ LDYDVGEEHQ SPGGISSEEE EEEEEEMLIS EEEIPFKDDP RDETYKPHLE RETPKPRRKS GKVKEEKEKK EIKVEVEVEV KEEENEIRED EEPPRKRGRR RKDDKSPRLP KRRKKPPIQY VRCEMEGCGT VLAHPRYLQH HIKYQHLLKK KYVCPHPSCG RLFRLQKQLL RHAKHHTDQR DYICEYCARA FKSSHNLAVH RMIHTGEKPL QCEICGFTCR QKASLNWHMK KHDADSFYQF SCNICGKKFE KKDSVVAHKA KSHPEVLIAE ALAANAGALI TSTDILGTNP ESLTQPSDGQ GLPLLPEPLG NSTSGECLLL EAEGMSKSYC SGTERVSLMA DGKIFVGSGS SGGTEGLVMN SDILGATTEV LIEDSDSAGP
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