About Solute carrier family 45 member 3
Solute carrier family 45 member 3 (SLC45A3) is a protein
from Homo sapiens identified by UniProt accession
Q96JT2, 553 residues long.
MolForge cross-references it against 0 known binders and
140 disease associations.
Target properties
| Protein name | Solute carrier family 45 member 3 |
|---|
| UniProt accession | Q96JT2 |
|---|
| Gene | SLC45A3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 553 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (140)
Diseases linked to this target (Open Targets).
- prostate adenocarcinoma · score 0.37
- sex hormone-binding globulin measurement · score 0.34
- basophil count · score 0.33
- PHF-tau measurement · score 0.25
- blood phosphate measurement · score 0.24
- eosinophil count · score 0.23
- basophil percentage of leukocytes · score 0.22
- basophil percentage of granulocytes · score 0.21
- melanoma · score 0.20
- prostate carcinoma · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96JT2-F1 | alphafold | PREDICTED | 76.65 | — |
Amino-acid sequence (553 residues)
MVQRLWVSRL LRHRKAQLLL VNLLTFGLEV CLAAGITYVP PLLLEVGVEE KFMTMVLGIG PVLGLVCVPL LGSASDHWRG RYGRRRPFIW ALSLGILLSL FLIPRAGWLA GLLCPDPRPL ELALLILGVG LLDFCGQVCF TPLEALLSDL FRDPDHCRQA YSVYAFMISL GGCLGYLLPA IDWDTSALAP YLGTQEECLF GLLTLIFLTC VAATLLVAEE AALGPTEPAE GLSAPSLSPH CCPCRARLAF RNLGALLPRL HQLCCRMPRT LRRLFVAELC SWMALMTFTL FYTDFVGEGL YQGVPRAEPG TEARRHYDEG VRMGSLGLFL QCAISLVFSL VMDRLVQRFG TRAVYLASVA AFPVAAGATC LSHSVAVVTA SAALTGFTFS ALQILPYTLA SLYHREKQVF LPKYRGDTGG ASSEDSLMTS FLPGPKPGAP FPNGHVGAGG SGLLPPPPAL CGASACDVSV RVVVGEPTEA RVVPGRGICL DLAILDSAFL LSQVAPSLFM GSIVQLSQSV TAYMVSAAGL GLVAIYFATQ VVFDKSDLAK YSA
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