TNFAIP3-interacting protein 3 (TNIP3)

About TNFAIP3-interacting protein 3

TNFAIP3-interacting protein 3 (TNIP3) is a protein from Homo sapiens identified by UniProt accession Q96KP6, 325 residues long. MolForge cross-references it against 0 known binders and 67 disease associations.

Target properties

Protein name	TNFAIP3-interacting protein 3
UniProt accession	Q96KP6
Gene	TNIP3
Organism	Homo sapiens
Length	325 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (67)

Diseases linked to this target (Open Targets).

multiple sclerosis · score 0.32
ovarian cancer · score 0.23
glioblastoma multiforme · score 0.23
squamous cell lung carcinoma · score 0.18
endometrial cancer · score 0.18
head and neck squamous cell carcinoma · score 0.18
gastric adenocarcinoma · score 0.18
lung adenocarcinoma · score 0.18
prostate adenocarcinoma · score 0.12
cardiac hypertrophy · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96KP6-F1	alphafold	PREDICTED	79.12	—

Amino-acid sequence (325 residues)

MAHFVQGTSR MIAAESSTEH KECAEPSTRK NLMNSLEQKI RCLEKQRKEL LEVNQQWDQQ FRSMKELYER KVAELKTKLD AAERFLSTRE KDPHQRQRKD DRQREDDRQR DLTRDRLQRE EKEKERLNEE LHELKEENKL LKGKNTLANK EKEHYECEIK RLNKALQDAL NIKCSFSEDC LRKSRVEFCH EEMRTEMEVL KQQVQIYEED FKKERSDRER LNQEKEELQQ INETSQSQLN RLNSQIKACQ MEKEKLEKQL KQMYCPPCNC GLVFHLQDPW VPTGPGAVQK QREHPPDYQW YALDQLPPDV QHKANGLSSV KKVHP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards