About Alpha-protein kinase 3
Alpha-protein kinase 3 (ALPK3) is a protein
from Homo sapiens identified by UniProt accession
Q96L96, 1705 residues long.
MolForge cross-references it against 0 known binders and
253 disease associations.
Target properties
| Protein name | Alpha-protein kinase 3 |
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| UniProt accession | Q96L96 |
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| Gene | ALPK3 |
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| Organism | Homo sapiens |
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| Length | 1705 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (253)
Diseases linked to this target (Open Targets).
- hypertrophic cardiomyopathy · score 0.78
- Abnormality of the cardiovascular system · score 0.55
- cardiomyopathy · score 0.50
- Neurodevelopmental disorder · score 0.43
- neurodegenerative disease · score 0.31
- mean corpuscular volume · score 0.27
- keratitis · score 0.23
- PR interval · score 0.23
- aspartate aminotransferase measurement · score 0.19
- Left ventricular mass to end-diastolic volume ratio · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96L96-F1 | alphafold | PREDICTED | 48.17 | — |
Amino-acid sequence (1705 residues)
MGSRRAPSRG WGAGGRSGAG GDGEDDGPVW IPSPASRSYL LSVRPETSLS SNRLSHPSSG RSTFCSIIAQ LTEETQPLFE TTLKSRSVSE DSDVRFTCIV TGYPEPEVTW YKDDTELDRY CGLPKYEITH QGNRHTLQLY RCREEDAAIY QASAQNSKGI VSCSGVLEVG TMTEYKIHQR WFAKLKRKAA AKLREIEQSW KHEKAVPGEV DTLRKLSPDR FQRKRRLSGA QAPGPSVPTR EPEGGTLAAW QEGETETAQH SGLGLINSFA SGEVTTNGEA APENGEDGEH GLLTYICDAM ELGPQRALKE ESGAKKKKKD EESKQGLRKP ELEKAAQSRR SSENCIPSSD EPDSCGTQGP VGVEQVQTQP RGRAARGPGS SGTDSTRKPA SAVGTPDKAQ KAPGPGPGQE VYFSLKDMYL ENTQAVRPLG EEGPQTLSVR APGESPKGKA PLRARSEGVP GAPGQPTHSL TPQPTRPFNR KRFAPPKPKG EATTDSKPIS SLSQAPECGA QSLGKAPPQA SVQVPTPPAR RRHGTRDSTL QGQAGHRTPG EVLECQTTTA PTMSASSSSD VASIGVSTSG SQGIIEPMDM ETQEDGRTSA NQRTGSKKNV QADGKIQVDG RTRGDGTQTA QRTRADRKTQ VDAGTQESKR PQSDRSAQKG MMTQGRAETQ LETTQAGEKI QEDRKAQADK GTQEDRRMQG EKGMQGEKGT QSEGSAPTAM EGQSEQEVAT SLGPPSRTPK LPPTAGPRAP LNIECFVQTP EGSCFPKKPG CLPRSEEAVV TASRNHEQTV LGPLSGNLML PAQPPHEGSV EQVGGERCRG PQSSGPVEAK QEDSPFQCPK EERPGGVPCM DQGGCPLAGL SQEVPTMPSL PGTGLTASPK AGPCSTPTSQ HGSTATFLPS EDQVLMSSAP TLHLGLGTPT QSHPPETMAT SSEGACAQVP DVEGRTPGPR SCDPGLIDSL KNYLLLLLKL SSTETSGAGG ESQVGAATGG LVPSATLTPT VEVAGLSPRT SRRILERVEN NHLVQSAQTL LLSPCTSRRL TGLLDREVQA GRQALAAARG SWGPGPSSLT VPAIVVDEED PGLASEGASE GEGEVSPEGP GLLGASQESS MAGRLGEAGG QAAPGQGPSA ESIAQEPSQE EKFPGEALTG LPAATPEELA LGARRKRFLP KVRAAGDGEA TTPEERESPT VSPRGPRKSL VPGSPGTPGR ERRSPTQGRK ASMLEVPRAE EELAAGDLGP SPKAGGLDTE VALDEGKQET LAKPRKAKDL LKAPQVIRKI RVEQFPDASG SLKLWCQFFN ILSDSVLTWA KDQRPVGEVG RSAGDEGPAA LAIVQASPVD CGVYRCTIHN EHGSASTDFC LSPEVLSGFI SREEGEVGEE IEMTPMVFAK GLADSGCWGD KLFGRLVSEE LRGGGYGCGL RKASQAKVIY GLEPIFESGR TCIIKVSSLL VFGPSSETSL VGRNYDVTIQ GCKIQNMSRE YCKIFAAEAR AAPGFGEVPE IIPLYLIYRP ANNIPYATLE EDLGKPLESY CSREWGCAEA PTASGSSEAM QKCQTFQHWL YQWTNGSFLV TDLAGVDWKM TDVQIATKLR GYQGLKESCF PALLDRFASS HQCNAYCELL GLTPLKGPEA AHPQAKAKGS KSPSAGRKGS QLSPQPQKKG LPSPQGTRKS APSSKATPQA SEPVTTQLLG QPPTQEEGSK AQGMR
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