About Calcineurin subunit B type 2
Calcineurin subunit B type 2 (PPP3R2) is a protein
from Homo sapiens identified by UniProt accession
Q96LZ3, 170 residues long.
MolForge cross-references it against 0 known binders and
105 disease associations.
Target properties
| Protein name | Calcineurin subunit B type 2 |
|---|
| UniProt accession | Q96LZ3 |
|---|
| Gene | PPP3R2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 170 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (105)
Diseases linked to this target (Open Targets).
- mathematical ability · score 0.12
- self reported educational attainment · score 0.12
- azoospermia · score 0.11
- male infertility with teratozoospermia due to single gene mutation · score 0.10
- alkaline phosphatase measurement · score 0.08
- spermatogenic failure 45 · score 0.08
- spermatogenic failure 43 · score 0.08
- spermatogenic failure 49 · score 0.08
- spermatogenic failure 19 · score 0.08
- spermatogenic failure 46 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96LZ3-F1 | alphafold | PREDICTED | 91.66 | — |
Amino-acid sequence (170 residues)
MGNEASYPAE MCSHFDNDEI KRLGRRFKKL DLDKSGSLSV EEFMSLPELR HNPLVRRVID VFDTDGDGEV DFKEFILGTS QFSVKGDEEQ KLRFAFSIYD MDKDGYISNG ELFQVLKMMV GNNLTDWQLQ QLVDKTIIIL DKDGDGKISF EEFSAVVRDL EIHKKLVLIV
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