Integrator complex subunit 15 (INTS15)

About Integrator complex subunit 15

Integrator complex subunit 15 (INTS15) is a protein from Homo sapiens identified by UniProt accession Q96N11, 449 residues long. MolForge cross-references it against 0 known binders and 152 disease associations.

Target properties

Protein name	Integrator complex subunit 15
UniProt accession	Q96N11
Gene	INTS15
Organism	Homo sapiens
Length	449 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (152)

Diseases linked to this target (Open Targets).

retinitis pigmentosa · score 0.07
congenital primary aphakia · score 0.07
mean corpuscular hemoglobin concentration · score 0.07
aniridia · score 0.06
Familial exudative vitreoretinopathy · score 0.06
uveal coloboma-cleft lip and palate-intellectual disability · score 0.06
Familial ocular anterior segment mesenchymal dysgenesis · score 0.06
Microphthalmia - cataract · score 0.06
autosomal dominant keratitis · score 0.06
isolated aniridia · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96N11-F1	alphafold	PREDICTED	82.51	—

Amino-acid sequence (449 residues)

MSDIRHSLLR RDALSAAKEV LYHLDIYFSS QLQSAPLPIV DKGPVELLEE FVFQVPKERS AQPKRLNSLQ ELQLLEIMCN YFQEQTKDSV RQIIFSSLFS PQGNKADDSR MSLLGKLVSM AVAVCRIPVL ECAASWLQRT PVVYCVRLAK ALVDDYCCLV PGSIQTLKQI FSASPRFCCQ FITSVTALYD LSSDDLIPPM DLLEMIVTWI FEDPRLILIT FLNTPIAANL PIGFLELTPL VGLIRWCVKA PLAYKRKKKP PLSNGHVSNK VTKDPGVGMD RDSHLLYSKL HLSVLQVLMT LQLHLTEKNL YGRLGLILFD HMVPLVEEIN RLADELNPLN ASQEIELSLD RLAQALQVAM ASGALLCTRD DLRTLCSRLP HNNLLQLVIS GPVQQSPHAA LPPGFYPHIH TPPLGYGAVP AHPAAHPALP THPGHTFISG VTFPFRPIR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards