Integral membrane protein GPR137 (GPR137)

About Integral membrane protein GPR137

Integral membrane protein GPR137 (GPR137) is a protein from Homo sapiens identified by UniProt accession Q96N19, 417 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.

Target properties

Protein name	Integral membrane protein GPR137
UniProt accession	Q96N19
Gene	GPR137
Organism	Homo sapiens
Length	417 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (71)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
heel bone mineral density · score 0.17
platelet count · score 0.13
urate measurement · score 0.09
attention deficit hyperactivity disorder · score 0.09
red blood cell density measurement · score 0.08
urinary bladder carcinoma · score 0.07
schizophrenia 15 · score 0.07
attention deficit-hyperactivity disorder 8 · score 0.07
body mass index · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96N19-F1	alphafold	PREDICTED	66.17	—

Amino-acid sequence (417 residues)

MESNLSGLVP AAGLVPALPP AVTLGLTAAY TTLYALLFFS VYAQLWLVLL YGHKRLSYQT VFLALCLLWA ALRTTLFSFY FRDTPRANRL GPLPFWLLYC CPVCLQFFTL TLMNLYFAQV VFKAKVKRRP EMSRGLLAVR GAFVGASLLF LLVNVLCAVL SHRRRAQPWA LLLVRVLVSD SLFVICALSL AACLCLVARR APSTSIYLEA KGTSVCQAAA MGGAMVLLYA SRACYNLTAL ALAPQSRLDT FDYDWYNVSD QADLVNDLGN KGYLVFGLIL FVWELLPTTL LVGFFRVHRP PQDLSTSHIL NGQVFASRSY FFDRAGHCED EGCSWEHSRG ESTRCQDQAA TTTVSTPPHR RDPPPSPTEY PGPSPPHPRP LCQVCLPLLA QDPGGRGYPL LWPAPCCSCH SELVPSP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards