TOX high mobility group box family member 2 (TOX2)

About TOX high mobility group box family member 2

TOX high mobility group box family member 2 (TOX2) is a protein from Homo sapiens identified by UniProt accession Q96NM4, 488 residues long. MolForge cross-references it against 0 known binders and 95 disease associations.

Target properties

Protein name	TOX high mobility group box family member 2
UniProt accession	Q96NM4
Gene	TOX2
Organism	Homo sapiens
Length	488 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (95)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.45
eosinophil count · score 0.45
erythrocyte count · score 0.42
mean corpuscular hemoglobin · score 0.41
leukocyte count · score 0.40
mean corpuscular hemoglobin concentration · score 0.39
colorectal cancer · score 0.39
Red cell distribution width · score 0.39
eosinophil percentage of leukocytes · score 0.34
calcium measurement · score 0.33

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96NM4-F1	alphafold	PREDICTED	51.46	—

Amino-acid sequence (488 residues)

MQQTRTEAVA GAFSRCLGFC GMRLGLLLLA RHWCIAGVFP QKFDGDSAYV GMSDGNPELL STSQTYNGQS ENNEDYEIPP ITPPNLPEPS LLHLGDHEAS YHSLCHGLTP NGLLPAYSYQ AMDLPAIMVS NMLAQDSHLL SGQLPTIQEM VHSEVAAYDS GRPGPLLGRP AMLASHMSAL SQSQLISQMG IRSSIAHSSP SPPGSKSATP SPSSSTQEEE SEVHFKISGE KRPSADPGKK AKNPKKKKKK DPNEPQKPVS AYALFFRDTQ AAIKGQNPSA TFGDVSKIVA SMWDSLGEEQ KQSSPDQGET KSTQANPPAK MLPPKQPMYA MPGLASFLTP SDLQAFRSGA SPASLARTLG SKSLLPGLSA SPPPPPSFPL SPTLHQQLSL PPHAQGALLS PPVSMSPAPQ PPVLPTPMAL QVQLAMSPSP PGPQDFPHIS EFPSSSGSCS PGPSNPTSSG DWDSSYPSGE CGISTCSLLP RDKSLYLT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards