Ankyrin repeat and SOCS box protein 16 (ASB16)

About Ankyrin repeat and SOCS box protein 16

Ankyrin repeat and SOCS box protein 16 (ASB16) is a protein from Homo sapiens identified by UniProt accession Q96NS5, 453 residues long. MolForge cross-references it against 0 known binders and 75 disease associations.

Target properties

Protein name	Ankyrin repeat and SOCS box protein 16
UniProt accession	Q96NS5
Gene	ASB16
Organism	Homo sapiens
Length	453 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (75)

Diseases linked to this target (Open Targets).

HbA1c measurement · score 0.25
hematocrit · score 0.21
mean platelet volume · score 0.21
body mass index · score 0.20
calcium measurement · score 0.19
body weight · score 0.19
clear cell renal carcinoma · score 0.18
bipolar disorder · score 0.18
body fat distribution · score 0.18
red blood cell density measurement · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96NS5-F1	alphafold	PREDICTED	88.98	—

Amino-acid sequence (453 residues)

MARETFPFTS SMLRSLRLQQ EWLEWEDRRR AAAQQCRSRR CPSSPRARLT RPHRSCRDPA VHQALFSGNL QQVQALFQDE EAANMIVETV SNQLAWSAEQ GFWVLTPKTK QTAPLAIATA RGYTDCARHL IRQGAELDAR VGGRAALHEA CARAQFDCVR LLLTFGAKAN VLTEEGTTPL HLCTIPESLQ CAKLLLEAGA TVNLAAGESQ ETPLHVAAAR GLEQHVALYL EHGADVGLRT SQGETALNTA CAGAEGPGSC RRHQAAARRL LEAGADARAA GRKRHTPLHN ACANGCGGLA ELLLRYGARA EVPNGAGHTP MDCALQAVQD SPNWEPEVLF AALLDYGAQP VRPEMLKHCA NFPRALEVLL NAYPCVPSCE TWVEAVLPEL WKEHEAFYSS ALCMVNQPRQ LQHLARLAVR ARLGSRCRQG ATRLPLPPLL RDYLLLRVEG CIQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards