About Sialic acid-binding Ig-like lectin 12
Sialic acid-binding Ig-like lectin 12 (SIGLEC12) is a protein
from Homo sapiens identified by UniProt accession
Q96PQ1, 595 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Sialic acid-binding Ig-like lectin 12 |
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| UniProt accession | Q96PQ1 |
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| Gene | SIGLEC12 |
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| Organism | Homo sapiens |
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| Length | 595 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (33)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.34
- neutrophil immunodeficiency syndrome · score 0.08
- Recurrent infection due to specific granule deficiency · score 0.05
- carcinoma · score 0.05
- immunodeficiency 35 · score 0.05
- immunodeficiency 81 · score 0.04
- cancer · score 0.04
- hyper-IgM syndrome type 2 · score 0.04
- immunodeficiency, common variable, 4 · score 0.04
- X-linked agammaglobulinemia · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96PQ1-F1 | alphafold | PREDICTED | 75.42 | — |
Amino-acid sequence (595 residues)
MLLLLLLLPP LLCGRVGAKE QKDYLLTMQK SVTVQEGLCV SVLCSFSYPQ NGWTASDPVH GYWFRAGDHV SRNIPVATNN PARAVQEETR DRFHLLGDPQ NKDCTLSIRD TRESDAGTYV FCVERGNMKW NYKYDQLSVN VTASQDLLSR YRLEVPESVT VQEGLCVSVP CSVLYPHYNW TASSPVYGSW FKEGADIPWD IPVATNTPSG KVQEDTHGRF LLLGDPQTNN CSLSIRDARK GDSGKYYFQV ERGSRKWNYI YDKLSVHVTA LTHMPTFSIP GTLESGHPRN LTCSVPWACE QGTPPTITWM GASVSSLDPT ITRSSMLSLI PQPQDHGTSL TCQVTLPGAG VTMTRAVRLN ISYPPQNLTM TVFQGDGTAS TTLRNGSALS VLEGQSLHLV CAVDSNPPAR LSWTWGSLTL SPSQSSNLGV LELPRVHVKD EGEFTCRAQN PLGSQHISLS LSLQNEYTGK MRPISGVTLG AFGGAGATAL VFLYFCIIFV VVRSCRKKSA RPAVGVGDTG MEDANAVRGS ASQGPLIESP ADDSPPHHAP PALATPSPEE GEIQYASLSF HKARPQYPQE QEAIGYEYSE INIPK
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