Paraneoplastic antigen-like protein 5 (PNMA5)

About Paraneoplastic antigen-like protein 5

Paraneoplastic antigen-like protein 5 (PNMA5) is a protein from Homo sapiens identified by UniProt accession Q96PV4, 448 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.

Target properties

Protein name	Paraneoplastic antigen-like protein 5
UniProt accession	Q96PV4
Gene	PNMA5
Organism	Homo sapiens
Length	448 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (12)

Diseases linked to this target (Open Targets).

non-small cell lung carcinoma · score 0.08
central nervous system cancer · score 0.04
glioblastoma multiforme · score 0.03
cancer · score 0.02
Benign Ovarian Neoplasm · score 0.01
neoplasm · score 0.01
Carcinoma, Lewis Lung · score 0.01
hepatocellular carcinoma · score 0.00
Neoplasm of the lung · score 0.00
glioblastoma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96PV4-F1	alphafold	PREDICTED	69.56	—

Amino-acid sequence (448 residues)

MALTLLEDWC KGMDMDPRKA LLIVGIPMEC SEVEIQDTVK AGLQPLCAYR VLGRMFRRED NAKAVFIELA DTVNYTTLPS HIPGKGGSWE VVVKPRNPDD EFLSRLNYFL KDEGRSMTDV ARALGCCSLP AESLDAEVMP QVRSPPLEPP KESMWYRKLK VFSGTASPSP GEETFEDWLE QVTEIMPIWQ VSEVEKRRRL LESLRGPALS IMRVLQANND SITVEQCLDA LKQIFGDKED FRASQFRFLQ TSPKIGEKVS TFLLRLEPLL QKAVHKSPLS VRSTDMIRLK HLLARVAMTP ALRGKLELLD QRGCPPNFLE LMKLIRDEEE WENTEAVMKN KEKPSGRGRG ASGRQARAEA SVSAPQATVQ ARSFSDSSPQ TIQGGLPPLV KRRRLLGSES TRGEDHGQAT YPKAENQTPG REGPQAAGEE LGNEAGAGAM SHPKPWET

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards