About CCA tRNA nucleotidyltransferase 1, mitochondrial
CCA tRNA nucleotidyltransferase 1, mitochondrial (TRNT1) is a protein
from Homo sapiens identified by UniProt accession
Q96Q11, 434 residues long.
MolForge cross-references it against 0 known binders and
100 disease associations.
Target properties
| Protein name | CCA tRNA nucleotidyltransferase 1, mitochondrial |
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| UniProt accession | Q96Q11 |
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| Gene | TRNT1 |
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| Organism | Homo sapiens |
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| Length | 434 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (100)
Diseases linked to this target (Open Targets).
- congenital sideroblastic anemia-B-cell immunodeficiency-periodic fever-developmental delay syndrome · score 0.82
- retinitis pigmentosa and erythrocytic microcytosis · score 0.73
- basophil count · score 0.41
- Retinal dystrophy · score 0.41
- autosomal recessive non-syndromic intellectual disability · score 0.40
- Sideroblastic anemia · score 0.37
- eosinophil count · score 0.35
- neurodegenerative disease · score 0.29
- basophil percentage of leukocytes · score 0.28
- multiple myeloma · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96Q11-F1 | alphafold | PREDICTED | 90.34 | — |
Amino-acid sequence (434 residues)
MLRCLYHWHR PVLNRRWSRL CLPKQYLFTM KLQSPEFQSL FTEGLKSLTE LFVKENHELR IAGGAVRDLL NGVKPQDIDF ATTATPTQMK EMFQSAGIRM INNRGEKHGT ITARLHEENF EITTLRIDVT TDGRHAEVEF TTDWQKDAER RDLTINSMFL GFDGTLFDYF NGYEDLKNKK VRFVGHAKQR IQEDYLRILR YFRFYGRIVD KPGDHDPETL EAIAENAKGL AGISGERIWV ELKKILVGNH VNHLIHLIYD LDVAPYIGLP ANASLEEFDK VSKNVDGFSP KPVTLLASLF KVQDDVTKLD LRLKIAKEEK NLGLFIVKNR KDLIKATDSS DPLKPYQDFI IDSREPDATT RVCELLKYQG EHCLLKEMQQ WSIPPFPVSG HDIRKVGISS GKEIGALLQQ LREQWKKSGY QMEKDELLSY IKKT
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