About Ankyrin repeat and SOCS box protein 2
Ankyrin repeat and SOCS box protein 2 (ASB2) is a protein
from Homo sapiens identified by UniProt accession
Q96Q27, 635 residues long.
MolForge cross-references it against 0 known binders and
86 disease associations.
Target properties
| Protein name | Ankyrin repeat and SOCS box protein 2 |
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| UniProt accession | Q96Q27 |
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| Gene | ASB2 |
|---|
| Organism | Homo sapiens |
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| Length | 635 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (86)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.48
- eosinophil percentage of leukocytes · score 0.44
- sum of eosinophil and basophil counts · score 0.31
- neutrophil percentage of granulocytes · score 0.31
- eosinophil percentage of granulocytes · score 0.31
- neurofibrillary tangles measurement · score 0.30
- monocyte count · score 0.22
- genetic disorder · score 0.12
- 3-hydroxy-1-methylpropylmercapturic acid measurement · score 0.09
- FEV/FVC ratio · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96Q27-F1 | alphafold | PREDICTED | 83.68 | — |
Amino-acid sequence (635 residues)
MATQISTRGS QCTIGQEEYS LYSSLSEDEL VQMAIEQSLA DKTRGPTTAE ATASACTNRQ PAHFYPWTRS TAPPESSPAR APMGLFQGVM QKYSSSLFKT SQLAPADPLI KAIKDGDEEA LKTMIKEGKN LAEPNKEGWL PLHEAAYYGQ VGCLKVLQRA YPGTIDQRTL QEETAVYLAT CRGHLDCLLS LLQAGAEPDI SNKSRETPLY KACERKNAEA VKILVQHNAD TNHRCNRGWT ALHESVSRND LEVMQILVSG GAKVESKNAY GITPLFVAAQ SGQLEALRFL AKYGADINTQ ASDNASALYE ACKNEHEEVV EFLLSQGADA NKTNKDGLLP LHIASKKGNY RIVQMLLPVT SRTRIRRSGV SPLHLAAERN HDEVLEALLS ARFDVNTPLA PERARLYEDR RSSALYFAVV NNNVYATELL LQHGADPNRD VISPLLVAIR HGCLRTMQLL LDHGANIDAY IATHPTAFPA TIMFAMKCLS LLKFLMDLGC DGEPCFSCLY GNGPHPPAPQ PSSRFNDAPA ADKEPSVVQF CEFVSAPEVS RWAGPIIDVL LDYVGNVQLC SRLKEHIDSF EDWAVIKEKA EPPRPLAHLC RLRVRKAIGK YRIKLLDTLP LPGRLIRYLK YENTQ
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