About Proton myo-inositol cotransporter
Proton myo-inositol cotransporter (SLC2A13) is a protein
from Homo sapiens identified by UniProt accession
Q96QE2, 648 residues long.
MolForge cross-references it against 0 known binders and
65 disease associations.
Target properties
| Protein name | Proton myo-inositol cotransporter |
|---|
| UniProt accession | Q96QE2 |
|---|
| Gene | SLC2A13 |
|---|
| Organism | Homo sapiens |
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| Length | 648 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (65)
Diseases linked to this target (Open Targets).
- Parkinson disease · score 0.41
- low density lipoprotein cholesterol measurement · score 0.36
- progressive supranuclear palsy · score 0.28
- overall survival · score 0.28
- inflammatory bowel disease · score 0.25
- myeloid white cell count · score 0.23
- serum gamma-glutamyl transferase measurement · score 0.23
- Crohn's disease · score 0.22
- mean platelet volume · score 0.21
- MODY · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96QE2-F1 | alphafold | PREDICTED | 80.03 | — |
Amino-acid sequence (648 residues)
MSRKASENVE YTLRSLSSLM GERRRKQPEP DAASAAGECS LLAAAESSTS LQSAGAGGGG VGDLERAARR QFQQDETPAF VYVVAVFSAL GGFLFGYDTG VVSGAMLLLK RQLSLDALWQ ELLVSSTVGA AAVSALAGGA LNGVFGRRAA ILLASALFTA GSAVLAAANN KETLLAGRLV VGLGIGIASM TVPVYIAEVS PPNLRGRLVT INTLFITGGQ FFASVVDGAF SYLQKDGWRY MLGLAAVPAV IQFFGFLFLP ESPRWLIQKG QTQKARRILS QMRGNQTIDE EYDSIKNNIE EEEKEVGSAG PVICRMLSYP PTRRALIVGC GLQMFQQLSG INTIMYYSAT ILQMSGVEDD RLAIWLASVT AFTNFIFTLV GVWLVEKVGR RKLTFGSLAG TTVALIILAL GFVLSAQVSP RITFKPIAPS GQNATCTRYS YCNECMLDPD CGFCYKMNKS TVIDSSCVPV NKASTNEAAW GRCENETKFK TEDIFWAYNF CPTPYSWTAL LGLILYLVFF APGMGPMPWT VNSEIYPLWA RSTGNACSSG INWIFNVLVS LTFLHTAEYL TYYGAFFLYA GFAAVGLLFI YGCLPETKGK KLEEIESLFD NRLCTCGTSD SDEGRYIEYI RVKGSNYHLS DNDASDVE
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