About Nucleus accumbens-associated protein 1
Nucleus accumbens-associated protein 1 (NACC1) is a protein
from Homo sapiens identified by UniProt accession
Q96RE7, 527 residues long.
MolForge cross-references it against 0 known binders and
153 disease associations.
Target properties
| Protein name | Nucleus accumbens-associated protein 1 |
|---|
| UniProt accession | Q96RE7 |
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| Gene | NACC1 |
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| Organism | Homo sapiens |
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| Length | 527 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (153)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with epilepsy, cataracts, feeding difficulties, and delayed brain myelination · score 0.72
- genetic disorder · score 0.34
- serum non-albumin protein measurement · score 0.17
- self reported educational attainment · score 0.16
- memory performance · score 0.16
- body height · score 0.14
- Neurodevelopmental disorder · score 0.12
- Intellectual disability · score 0.12
- venous thromboembolism · score 0.12
- lymphocyte percentage of leukocytes · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96RE7-F1 | alphafold | PREDICTED | 63.06 | — |
Amino-acid sequence (527 residues)
MAQTLQMEIP NFGNSILECL NEQRLQGLYC DVSVVVKGHA FKAHRAVLAA SSSYFRDLFN NSRSAVVELP AAVQPQSFQQ ILSFCYTGRL SMNVGDQFLL MYTAGFLQIQ EIMEKGTEFF LKVSSPSCDS QGLHAEEAPS SEPQSPVAQT SGWPACSTPL PLVSRVKTEQ QESDSVQCMP VAKRLWDSGQ KEAGGGGNGS RKMAKFSTPD LAANRPHQPP PPQQAPVVAA AQPAVAAGAG QPAGGVAAAG GVVSGPSTSE RTSPGTSSAY TSDSPGSYHN EEDEEEDGGE EGMDEQYRQI CNMYTMYSMM NVGQTAEKVE ALPEQVAPES RNRIRVRQDL ASLPAELINQ IGNRCHPKLY DEGDPSEKLE LVTGTNVYIT RAQLMNCHVS AGTRHKVLLR RLLASFFDRN TLANSCGTGI RSSTNDPRRK PLDSRVLHAV KYYCQNFAPN FKESEMNAIA ADMCTNARRV VRKSWMPKVK VLKAEDDAYT TFISETGKIE PDMMGVEHGF ETASHEGEAG PSAEALQ
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