About Bile acid receptor
Bile acid receptor (NR1H4) is a protein
from Homo sapiens identified by UniProt accession
Q96RI1, 486 residues long.
MolForge cross-references it against 0 known binders and
599 disease associations.
Target properties
| Protein name | Bile acid receptor |
|---|
| UniProt accession | Q96RI1 |
|---|
| Gene | NR1H4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 486 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (599)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.62
- progressive familial intrahepatic cholestasis · score 0.62
- primary biliary cirrhosis · score 0.60
- morbid obesity · score 0.54
- biliary liver cirrhosis · score 0.53
- testosterone measurement · score 0.52
- alkaline phosphatase measurement · score 0.49
- low density lipoprotein cholesterol measurement · score 0.47
- progressive familial intrahepatic cholestasis type 1 · score 0.47
- ciliopathy · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96RI1-F1 | alphafold | PREDICTED | 68.83 | — |
Amino-acid sequence (486 residues)
MVMQFQGLEN PIQISPHCSC TPSGFFMEMM SMKPAKGVLT EQVAGPLGQN LEVEPYSQYS NVQFPQVQPQ ISSSSYYSNL GFYPQQPEEW YSPGIYELRR MPAETLYQGE TEVAEMPVTK KPRMGASAGR IKGDELCVVC GDRASGYHYN ALTCEGCKGF FRRSITKNAV YKCKNGGNCV MDMYMRRKCQ ECRLRKCKEM GMLAECMYTG LLTEIQCKSK RLRKNVKQHA DQTVNEDSEG RDLRQVTSTT KSCREKTELT PDQQTLLHFI MDSYNKQRMP QEITNKILKE EFSAEENFLI LTEMATNHVQ VLVEFTKKLP GFQTLDHEDQ IALLKGSAVE AMFLRSAEIF NKKLPSGHSD LLEERIRNSG ISDEYITPMF SFYKSIGELK MTQEEYALLT AIVILSPDRQ YIKDREAVEK LQEPLLDVLQ KLCKIHQPEN PQHFACLLGR LTELRTFNHH HAEMLMSWRV NDHKFTPLLC EIWDVQ
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