Cyclin-L2 (CCNL2)

About Cyclin-L2

Cyclin-L2 (CCNL2) is a protein from Homo sapiens identified by UniProt accession Q96S94, 520 residues long. MolForge cross-references it against 0 known binders and 74 disease associations.

Target properties

Protein name	Cyclin-L2
UniProt accession	Q96S94
Gene	CCNL2
Organism	Homo sapiens
Length	520 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (74)

Diseases linked to this target (Open Targets).

peak expiratory flow · score 0.15
body height · score 0.04
Drugs affecting bone structure and mineralization use measurement · score 0.04
osteoporosis · score 0.04
myxedema · score 0.04
heel bone mineral density · score 0.04
eosinophil count · score 0.03
inflammatory bowel disease · score 0.03
drug use measurement · score 0.03
Pallister-Hall syndrome · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96S94-F1	alphafold	PREDICTED	69.14	—

Amino-acid sequence (520 residues)

MAAAAAAAGA AGSAAPAAAA GAPGSGGAPS GSQGVLIGDR LYSGVLITLE NCLLPDDKLR FTPSMSSGLD TDTETDLRVV GCELIQAAGI LLRLPQVAMA TGQVLFQRFF YTKSFVKHSM EHVSMACVHL ASKIEEAPRR IRDVINVFHR LRQLRDKKKP VPLLLDQDYV NLKNQIIKAE RRVLKELGFC VHVKHPHKII VMYLQVLECE RNQHLVQTSW NYMNDSLRTD VFVRFQPESI ACACIYLAAR TLEIPLPNRP HWFLLFGATE EEIQEICLKI LQLYARKKVD LTHLEGEVEK RKHAIEEAKA QARGLLPGGT QVLDGTSGFS PAPKLVESPK EGKGSKPSPL SVKNTKRRLE GAKKAKADSP VNGLPKGRES RSRSRSREQS YSRSPSRSAS PKRRKSDSGS TSGGSKSQSR SRSRSDSPPR QAPRSAPYKG SEIRGSRKSK DCKYPQKPHK SRSRSSSRSR SRSRERADNP GKYKKKSHYY RDQRRERSRS YERTGRRYER DHPGHSRHRR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards