About Protein artemis
Protein artemis (DCLRE1C) is a protein
from Homo sapiens identified by UniProt accession
Q96SD1, 692 residues long.
MolForge cross-references it against 0 known binders and
267 disease associations.
Target properties
| Protein name | Protein artemis |
|---|
| UniProt accession | Q96SD1 |
|---|
| Gene | DCLRE1C |
|---|
| Organism | Homo sapiens |
|---|
| Length | 692 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (267)
Diseases linked to this target (Open Targets).
- severe combined immunodeficiency due to DCLRE1C deficiency · score 0.81
- Omenn syndrome · score 0.70
- histiocytic medullary reticulosis · score 0.56
- severe combined immunodeficiency · score 0.54
- Combined immunodeficiency · score 0.46
- combined immunodeficiency · score 0.46
- T-B+ severe combined immunodeficiency · score 0.46
- T-B- severe combined immunodeficiency · score 0.46
- lymphocyte count · score 0.37
- Ehlers-Danlos syndrome, musculocontractural type · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96SD1-F1 | alphafold | PREDICTED | 69.44 | — |
Amino-acid sequence (692 residues)
MSSFEGQMAE YPTISIDRFD RENLRARAYF LSHCHKDHMK GLRAPTLKRR LECSLKVYLY CSPVTKELLL TSPKYRFWKK RIISIEIETP TQISLVDEAS GEKEEIVVTL LPAGHCPGSV MFLFQGNNGT VLYTGDFRLA QGEAARMELL HSGGRVKDIQ SVYLDTTFCD PRFYQIPSRE ECLSGVLELV RSWITRSPYH VVWLNCKAAY GYEYLFTNLS EELGVQVHVN KLDMFRNMPE ILHHLTTDRN TQIHACRHPK AEEYFQWSKL PCGITSRNRI PLHIISIKPS TMWFGERSRK TNVIVRTGES SYRACFSFHS SYSEIKDFLS YLCPVNAYPN VIPVGTTMDK VVEILKPLCR SSQSTEPKYK PLGKLKRART VHRDSEEEDD YLFDDPLPIP LRHKVPYPET FHPEVFSMTA VSEKQPEKLR QTPGCCRAEC MQSSRFTNFV DCEESNSESE EEVGIPASLQ GDLGSVLHLQ KADGDVPQWE VFFKRNDEIT DESLENFPSS TVAGGSQSPK LFSDSDGEST HISSQNSSQS THITEQGSQG WDSQSDTVLL SSQERNSGDI TSLDKADYRP TIKENIPASL MEQNVICPKD TYSDLKSRDK DVTIVPSTGE PTTLSSETHI PEEKSLLNLS TNADSQSSSD FEVPSTPEAE LPKREHLQYL YEKLATGESI AVKKRKCSLL DT
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