About Tetraspanin-18
Tetraspanin-18 (TSPAN18) is a protein
from Homo sapiens identified by UniProt accession
Q96SJ8, 248 residues long.
MolForge cross-references it against 0 known binders and
91 disease associations.
Target properties
| Protein name | Tetraspanin-18 |
|---|
| UniProt accession | Q96SJ8 |
|---|
| Gene | TSPAN18 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 248 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (91)
Diseases linked to this target (Open Targets).
- brain measurement · score 0.33
- intraocular pressure measurement · score 0.33
- schizophrenia · score 0.32
- serum metabolite measurement · score 0.26
- neoplasm · score 0.09
- glioblastoma multiforme · score 0.07
- MODY · score 0.07
- cancer · score 0.06
- diabetes mellitus, permanent neonatal 4 · score 0.05
- diabetes mellitus, transient neonatal, 3 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96SJ8-F1 | alphafold | PREDICTED | 90.61 | — |
Amino-acid sequence (248 residues)
MEGDCLSCMK YLMFVFNFFI FLGGACLLAI GIWVMVDPTG FREIVAANPL LLTGAYILLA MGGLLFLLGF LGCCGAVREN KCLLLFFFLF ILIIFLAELS AAILAFIFRE NLTREFFTKE LTKHYQGNND TDVFSATWNS VMITFGCCGV NGPEDFKFAS VFRLLTLDSE EVPEACCRRE PQSRDGVLLS REECLLGRSL FLNKQGCYTV ILNTFETYVY LAGALAIGVL AIELFAMIFA MCLFRGIQ
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