About Transmembrane protein 209
Transmembrane protein 209 (TMEM209) is a protein
from Homo sapiens identified by UniProt accession
Q96SK2, 561 residues long.
MolForge cross-references it against 0 known binders and
82 disease associations.
Target properties
| Protein name | Transmembrane protein 209 |
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| UniProt accession | Q96SK2 |
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| Gene | TMEM209 |
|---|
| Organism | Homo sapiens |
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| Length | 561 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (82)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.15
- azoospermia · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.05
- partial chromosome Y deletion · score 0.05
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.05
- spermatogenic failure 61 · score 0.05
- spermatogenic failure 3 · score 0.05
- spermatogenic failure 55 · score 0.05
- spermatogenic failure 59 · score 0.05
- spermatogenic failure 73 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96SK2-F1 | alphafold | PREDICTED | 68.39 | — |
Amino-acid sequence (561 residues)
MMQGEAHPSA SLIDRTIKMR KETEARKVVL AWGLLNVSMA GMIYTEMTGK LISSYYNVTY WPLWYIELAL ASLFSLNALF DFWRYFKYTV APTSLVVSPG QQTLLGLKTA VVQTTPPHDL AATQIPPAPP SPSIQGQSVL SYSPSRSPST SPKFTTSCMT GYSPQLQGLS SGGSGSYSPG VTYSPVSGYN KLASFSPSPP SPYPTTVGPV ESSGLRSRYR SSPTVYNSPT DKEDYMTDLR TLDTFLRSEE EKQHRVKLGS PDSTSPSSSP TFWNYSRSMG DYAQTLKKFQ YQLACRSQAP CANKDEADLS SKQAAEEVWA RVAMNRQLLD HMDSWTAKFR NWINETILVP LVQEIESVST QMRRMGCPEL QIGEASITSL KQAALVKAPL IPTLNTIVQY LDLTPNQEYL FERIKELSQG GCMSSFRWNR GGDFKGRKWD TDLPTDSAII MHVFCTYLDS RLPPHPKYPD GKTFTSQHFV QTPNKPDVTN ENVFCIYQSA INPPHYELIY QRHVYNLPKG RNNMFHTLLM FLYIIKTKES GMLGRVNLGL SGVNILWIFG E
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