About Zinc finger protein ZIC 5
Zinc finger protein ZIC 5 (ZIC5) is a protein
from Homo sapiens identified by UniProt accession
Q96T25, 639 residues long.
MolForge cross-references it against 0 known binders and
67 disease associations.
Target properties
| Protein name | Zinc finger protein ZIC 5 |
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| UniProt accession | Q96T25 |
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| Gene | ZIC5 |
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| Organism | Homo sapiens |
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| Length | 639 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (67)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- heel bone mineral density · score 0.40
- bone quantitative ultrasound measurement · score 0.29
- cystatin C measurement · score 0.22
- refractive error · score 0.20
- smoking status measurement · score 0.19
- Myopia · score 0.18
- refractive error measurement · score 0.16
- age at onset · score 0.15
- Abnormality of refraction · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96T25-F1 | alphafold | PREDICTED | 51.54 | — |
Amino-acid sequence (639 residues)
MEPPLSKRNP PALRLADLAT AQVQPLQNMT GFPALAGPPA HSQLRAAVAH LRLRDLGADP GVATTPLGPE HMAQASTLGL SPPSQAFPAH PEAPAAAARA AALVAHPGAG SYPCGGGSSG AQPSAPPPPA PPLPPTPSPP PPPPPPPPPA LSGYTTTNSG GGGSSGKGHS RDFVLRRDLS ATAPAAAMHG APLGGEQRSG TGSPQHPAPP PHSAGMFISA SGTYAGPDGS GGPALFPALH DTPGAPGGHP HPLNGQMRLG LAAAAAAAAA ELYGRAEPPF APRSGDAHYG AVAAAAAAAL HGYGAVNLNL NLAAAAAAAA AGPGPHLQHH APPPAPPPPP APAQHPHQHH PHLPGAAGAF LRYMRQPIKQ ELICKWIDPD ELAGLPPPPP PPPPPPPPPP AGGAKPCSKT FGTMHELVNH VTVEHVGGPE QSSHVCFWED CPREGKPFKA KYKLINHIRV HTGEKPFPCP FPGCGKVFAR SENLKIHKRT HTGEKPFKCE FDGCDRKFAN SSDRKKHSHV HTSDKPYYCK IRGCDKSYTH PSSLRKHMKI HCKSPPPSPG PLGYSSVGTP VGAPLSPVLD PARSHSSTLS PQVTNLNEWY VCQASGAPSH LHTPSSNGTT SETEDEEIYG NPEVVRTIH
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