About Protein phosphatase 1 regulatory inhibitor subunit 16B
Protein phosphatase 1 regulatory inhibitor subunit 16B (PPP1R16B) is a protein
from Homo sapiens identified by UniProt accession
Q96T49, 567 residues long.
MolForge cross-references it against 0 known binders and
66 disease associations.
Target properties
| Protein name | Protein phosphatase 1 regulatory inhibitor subunit 16B |
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| UniProt accession | Q96T49 |
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| Gene | PPP1R16B |
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| Organism | Homo sapiens |
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| Length | 567 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (66)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- schizophrenia · score 0.43
- autism spectrum disorder · score 0.37
- platelet component distribution width · score 0.36
- attention deficit hyperactivity disorder · score 0.35
- self reported educational attainment · score 0.33
- unipolar depression · score 0.27
- bipolar disorder · score 0.27
- obsessive-compulsive disorder · score 0.27
- Tourette syndrome · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96T49-F1 | alphafold | PREDICTED | 70.51 | — |
Amino-acid sequence (567 residues)
MASHVDLLTE LQLLEKVPTL ERLRAAQKRR AQQLKKWAQY EQDLQHRKRK HERKRSTGGR RKKVSFEASV ALLEASLRND AEEVRYFLKN KVSPDLCNED GLTALHQCCI DNFEEIVKLL LSHGANVNAK DNELWTPLHA AATCGHINLV KILVQYGADL LAVNSDGNMP YDLCEDEPTL DVIETCMAYQ GITQEKINEM RVAPEQQMIA DIHCMIAAGQ DLDWIDAQGA TLLHIAGANG YLRAAELLLD HGVRVDVKDW DGWEPLHAAA FWGQMQMAEL LVSHGASLSA RTSMDEMPID LCEEEEFKVL LLELKHKHDV IMKSQLRHKS SLSRRTSSAG SRGKVVRRAS LSDRTNLYRK EYEGEAILWQ RSAAEDQRTS TYNGDIRETR TDQENKDPNP RLEKPVLLSE FPTKIPRGEL DMPVENGLRA PVSAYQYALA NGDVWKVHEV PDYSMAYGNP GVADATPPWS SYKEQSPQTL LELKRQRAAA KLLSHPFLST HLGSSMARTG ESSSEGKAPL IGGRTSPYSS NGTSVYYTVT SGDPPLLKFK APIEEMEEKV HGCCRIS
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