Potassium channel subfamily K member 17 (KCNK17)

About Potassium channel subfamily K member 17

Potassium channel subfamily K member 17 (KCNK17) is a protein from Homo sapiens identified by UniProt accession Q96T54, 332 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.

Target properties

Protein name	Potassium channel subfamily K member 17
UniProt accession	Q96T54
Gene	KCNK17
Organism	Homo sapiens
Length	332 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (62)

Diseases linked to this target (Open Targets).

type 2 diabetes mellitus · score 0.42
apolipoprotein B measurement · score 0.34
urate measurement · score 0.34
low density lipoprotein cholesterol measurement · score 0.33
total cholesterol measurement · score 0.28
uric acid measurement · score 0.28
serum albumin measurement · score 0.24
lung adenocarcinoma · score 0.23
waist-hip ratio · score 0.22
appendicular lean mass · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96T54-F1	alphafold	PREDICTED	76.88	—

Amino-acid sequence (332 residues)

MYRPRARAAP EGRVRGCAVP STVLLLLAYL AYLALGTGVF WTLEGRAAQD SSRSFQRDKW ELLQNFTCLD RPALDSLIRD VVQAYKNGAS LLSNTTSMGR WELVGSFFFS VSTITTIGYG NLSPNTMAAR LFCIFFALVG IPLNLVVLNR LGHLMQQGVN HWASRLGGTW QDPDKARWLA GSGALLSGLL LFLLLPPLLF SHMEGWSYTE GFYFAFITLS TVGFGDYVIG MNPSQRYPLW YKNMVSLWIL FGMAWLALII KLILSQLETP GRVCSCCHHS SKEDFKSQSW RQGPDREPES HSPQQGCYPE GPMGIIQHLE PSAHAAGCGK DS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards