Glycoprotein hormone alpha-2 (GPHA2)

About Glycoprotein hormone alpha-2

Glycoprotein hormone alpha-2 (GPHA2) is a protein from Homo sapiens identified by UniProt accession Q96T91, 129 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.

Target properties

Protein name	Glycoprotein hormone alpha-2
UniProt accession	Q96T91
Gene	GPHA2
Organism	Homo sapiens
Length	129 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (52)

Diseases linked to this target (Open Targets).

cutaneous melanoma · score 0.18
serum metabolite measurement · score 0.03
inflammatory bowel disease · score 0.02
ulcerative colitis · score 0.02
hepatitis B virus infection · score 0.01
neoplasm · score 0.01
infection · score 0.01
infect · score 0.01
appendicitis · score 0.01
adenocarcinoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96T91-F1	alphafold	PREDICTED	89.20	—

Amino-acid sequence (129 residues)

MPMASPQTLV LYLLVLAVTE AWGQEAVIPG CHLHPFNVTV RSDRQGTCQG SHVAQACVGH CESSAFPSRY SVLVASGYRH NITSVSQCCT ISGLKKVKVQ LQCVGSRREE LEIFTARACQ CDMCRLSRY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards