Chymotrypsin-C (CTRC)

About Chymotrypsin-C

Chymotrypsin-C (CTRC) is a protein from Homo sapiens identified by UniProt accession Q99895, 268 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.

Target properties

Protein name	Chymotrypsin-C
UniProt accession	Q99895
Gene	CTRC
Organism	Homo sapiens
Length	268 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (54)

Diseases linked to this target (Open Targets).

hereditary chronic pancreatitis · score 0.73
chronic pancreatitis · score 0.65
alcoholic pancreatitis · score 0.26
acute pancreatitis · score 0.25
blood protein measurement · score 0.16
head and neck squamous cell carcinoma · score 0.13
metabolite measurement · score 0.04
Hyperlipoproteinemia type 1 · score 0.04
Metaphyseal chondrodysplasia, Schmid type · score 0.04
spondyloepimetaphyseal dysplasia, Missouri type · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99895-F1	alphafold	PREDICTED	93.48	—

Amino-acid sequence (268 residues)

MLGITVLAAL LACASSCGVP SFPPNLSARV VGGEDARPHS WPWQISLQYL KNDTWRHTCG GTLIASNFVL TAAHCISNTR TYRVAVGKNN LEVEDEEGSL FVGVDTIHVH KRWNALLLRN DIALIKLAEH VELSDTIQVA CLPEKDSLLP KDYPCYVTGW GRLWTNGPIA DKLQQGLQPV VDHATCSRID WWGFRVKKTM VCAGGDGVIS ACNGDSGGPL NCQLENGSWE VFGIVSFGSR RGCNTRKKPV VYTRVSAYID WINEKMQL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards