About Calcium uptake protein 1, mitochondrial
Calcium uptake protein 1, mitochondrial (MICU1) is a protein
from Homo sapiens identified by UniProt accession
Q9BPX6, 476 residues long.
MolForge cross-references it against 0 known binders and
138 disease associations.
Target properties
| Protein name | Calcium uptake protein 1, mitochondrial |
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| UniProt accession | Q9BPX6 |
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| Gene | MICU1 |
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| Organism | Homo sapiens |
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| Length | 476 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (138)
Diseases linked to this target (Open Targets).
- proximal myopathy with extrapyramidal signs · score 0.77
- Neurodevelopmental disorder · score 0.43
- mitochondrial disease · score 0.37
- Abnormality of the nervous system · score 0.34
- Fabry disease · score 0.34
- Angiokeratoma corporis diffusum · score 0.34
- genetic disorder · score 0.34
- Red cell distribution width · score 0.32
- C-reactive protein measurement · score 0.25
- high density lipoprotein cholesterol measurement · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BPX6-F1 | alphafold | PREDICTED | 76.10 | — |
Amino-acid sequence (476 residues)
MFRLNSLSAL AELAVGSRWY HGGSQPIQIR RRLMMVAFLG ASAVTASTGL LWKRAHAESP PCVDNLKSDI GDKGKNKDEG DVCNHEKKTA DLAPHPEEKK KKRSGFRDRK VMEYENRIRA YSTPDKIFRY FATLKVISEP GEAEVFMTPE DFVRSITPNE KQPEHLGLDQ YIIKRFDGKK ISQEREKFAD EGSIFYTLGE CGLISFSDYI FLTTVLSTPQ RNFEIAFKMF DLNGDGEVDM EEFEQVQSII RSQTSMGMRH RDRPTTGNTL KSGLCSALTT YFFGADLKGK LTIKNFLEFQ RKLQHDVLKL EFERHDPVDG RITERQFGGM LLAYSGVQSK KLTAMQRQLK KHFKEGKGLT FQEVENFFTF LKNINDVDTA LSFYHMAGAS LDKVTMQQVA RTVAKVELSD HVCDVVFALF DCDGNGELSN KEFVSIMKQR LMRGLEKPKD MGFTRLMQAM WKCAQETAWD FALPKQ
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