Homeodomain-only protein (HOPX)

About Homeodomain-only protein

Homeodomain-only protein (HOPX) is a protein from Homo sapiens identified by UniProt accession Q9BPY8, 73 residues long. MolForge cross-references it against 0 known binders and 208 disease associations.

Target properties

Protein name	Homeodomain-only protein
UniProt accession	Q9BPY8
Gene	HOPX
Organism	Homo sapiens
Length	73 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (208)

Diseases linked to this target (Open Targets).

reticulocyte count · score 0.40
reticulocyte measurement · score 0.35
balding measurement · score 0.30
blood protein measurement · score 0.18
neoplasm · score 0.10
acute myeloid leukemia · score 0.08
oral squamous cell carcinoma · score 0.08
papillary thyroid carcinoma · score 0.08
hypertrophic cardiomyopathy · score 0.07
non-small cell lung carcinoma · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BPY8-F1	alphafold	PREDICTED	82.71	—

Amino-acid sequence (73 residues)

MSAETASGPT EDQVEILEYN FNKVDKHPDS TTLCLIAAEA GLSEEETQKW FKQRLAKWRR SEGLPSECRS VTD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards