Telomerase RNA component interacting RNase (TRIR)

About Telomerase RNA component interacting RNase

Telomerase RNA component interacting RNase (TRIR) is a protein from Homo sapiens identified by UniProt accession Q9BQ61, 176 residues long. MolForge cross-references it against 0 known binders and 7 disease associations.

Target properties

Protein name	Telomerase RNA component interacting RNase
UniProt accession	Q9BQ61
Gene	TRIR
Organism	Homo sapiens
Length	176 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (7)

Diseases linked to this target (Open Targets).

body height · score 0.02
triple-negative breast cancer · score 0.01
neoplasm · score 0.00
acute megakaryoblastic leukaemia · score 0.00
cancer · score 0.00
melanoma · score 0.00
breast cancer · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BQ61-F1	alphafold	PREDICTED	61.97	—

Amino-acid sequence (176 residues)

MAARGRRAEP QGREAPGPAG GGGGGSRWAE SGSGTSPESG DEEVSGAGSS PVSGGVNLFA NDGSFLELFK RKMEEEQRQR QEEPPPGPQR PDQSAAAAGP GDPKRKGGPG STLSFVGKRR GGNKLALKTG IVAKKQKTED EVLTSKGDAW AKYMAEVKKY KAHQCGDDDK TRPLVK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards