About Ribosome quality control complex subunit TCF25
Ribosome quality control complex subunit TCF25 (TCF25) is a protein
from Homo sapiens identified by UniProt accession
Q9BQ70, 676 residues long.
MolForge cross-references it against 0 known binders and
79 disease associations.
Target properties
| Protein name | Ribosome quality control complex subunit TCF25 |
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| UniProt accession | Q9BQ70 |
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| Gene | TCF25 |
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| Organism | Homo sapiens |
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| Length | 676 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (79)
Diseases linked to this target (Open Targets).
- hair colour measurement · score 0.43
- reticulocyte count · score 0.32
- skin pigmentation · score 0.31
- hair color · score 0.31
- cutaneous melanoma · score 0.26
- facial pigmentation measurement · score 0.23
- prostate carcinoma · score 0.21
- white matter integrity · score 0.18
- heel bone mineral density · score 0.18
- sunburn · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BQ70-F1 | alphafold | PREDICTED | 72.04 | — |
Amino-acid sequence (676 residues)
MSRRALRRLR GEQRGQEPLG PGALHFDLRD DDDAEEEGPK RELGVRRPGG AGKEGVRVNN RFELINIDDL EDDPVVNGER SGCALTDAVA PGNKGRGQRG NTESKTDGDD TETVPSEQSH ASGKLRKKKK KQKNKKSSTG EASENGLEDI DRILERIEDS TGLNRPGPAP LSSRKHVLYV EHRHLNPDTE LKRYFGARAI LGEQRPRQRQ RVYPKCTWLT TPKSTWPRYS KPGLSMRLLE SKKGLSFFAF EHSEEYQQAQ HKFLVAVESM EPNNIVVLLQ TSPYHVDSLL QLSDACRFQE DQEMARDLVE RALYSMECAF HPLFSLTSGA CRLDYRRPEN RSFYLALYKQ MSFLEKRGCP RTALEYCKLI LSLEPDEDPL CMLLLIDHLA LRARNYEYLI RLFQEWEAHR NLSQLPNFAF SVPLAYFLLS QQTDLPECEQ SSARQKASLL IQQALTMFPG VLLPLLESCS VRPDASVSSH RFFGPNAEIS QPPALSQLVN LYLGRSHFLW KEPATMSWLE ENVHEVLQAV DAGDPAVEAC ENRRKVLYQR APRNIHRHVI LSEIKEAVAA LPPDVTTQSV MGFDPLPPSD TIYSYVRPER LSPISHGNTI ALFFRSLLPN YTMEGERPEE GVAGGLNRNQ GLNRLMLAVR DMMANFHLND LEAPHEDDAE GEGEWD
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