About Sclerostin
Sclerostin (SOST) is a protein
from Homo sapiens identified by UniProt accession
Q9BQB4, 213 residues long.
MolForge cross-references it against 0 known binders and
532 disease associations.
Target properties
| Protein name | Sclerostin |
|---|
| UniProt accession | Q9BQB4 |
|---|
| Gene | SOST |
|---|
| Organism | Homo sapiens |
|---|
| Length | 213 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (532)
Diseases linked to this target (Open Targets).
- sclerosteosis 1 · score 0.70
- craniodiaphyseal dysplasia · score 0.67
- hyperostosis corticalis generalisata · score 0.64
- osteoporosis · score 0.60
- postmenopausal osteoporosis · score 0.55
- sclerosteosis · score 0.39
- bone disease · score 0.38
- osteogenesis imperfecta · score 0.37
- heel bone mineral density · score 0.32
- bone fracture · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BQB4-F1 | alphafold | PREDICTED | 70.79 | — |
Amino-acid sequence (213 residues)
MQLPLALCLV CLLVHTAFRV VEGQGWQAFK NDATEIIPEL GEYPEPPPEL ENNKTMNRAE NGGRPPHHPF ETKDVSEYSC RELHFTRYVT DGPCRSAKPV TELVCSGQCG PARLLPNAIG RGKWWRPSGP DFRCIPDRYR AQRVQLLCPG GEAPRARKVR LVASCKCKRL TRFHNQSELK DFGTEAARPQ KGRKPRPRAR SAKANQAELE NAY
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