Vitamin K epoxide reductase complex subunit 1 (VKORC1)

About Vitamin K epoxide reductase complex subunit 1

Vitamin K epoxide reductase complex subunit 1 (VKORC1) is a protein from Homo sapiens identified by UniProt accession Q9BQB6, 163 residues long. MolForge cross-references it against 0 known binders and 304 disease associations.

Target properties

Protein name	Vitamin K epoxide reductase complex subunit 1
UniProt accession	Q9BQB6
Gene	VKORC1
Organism	Homo sapiens
Length	163 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (6)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (304)

Diseases linked to this target (Open Targets).

vitamin K-dependent clotting factors, combined deficiency of, type 2 · score 0.69
venous thromboembolism · score 0.62
atrial fibrillation · score 0.61
pulmonary embolism · score 0.57
deep vein thrombosis · score 0.57
cholesterol embolism · score 0.57
stroke · score 0.56
Venous thrombosis · score 0.56
Thromboembolism · score 0.56
myocardial infarction · score 0.54

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BQB6-F1	alphafold	PREDICTED	91.56	—

Amino-acid sequence (163 residues)

MGSTWGSPGW VRLALCLTGL VLSLYALHVK AARARDRDYR ALCDVGTAIS CSRVFSSRWG RGFGLVEHVL GQDSILNQSN SIFGCIFYTL QLLLGCLRTR WASVLMLLSS LVSLAGSVYL AWILFFVLYD FCIVCITTYA INVSLMWLSF RKVQEPQGKA KRH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards