About Phosphatidate phosphatase LPIN3
Phosphatidate phosphatase LPIN3 (LPIN3) is a protein
from Homo sapiens identified by UniProt accession
Q9BQK8, 851 residues long.
MolForge cross-references it against 0 known binders and
125 disease associations.
Target properties
| Protein name | Phosphatidate phosphatase LPIN3 |
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| UniProt accession | Q9BQK8 |
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| Gene | LPIN3 |
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| Organism | Homo sapiens |
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| Length | 851 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (125)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.19
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.18
- platelet count · score 0.17
- body height · score 0.16
- high density lipoprotein cholesterol measurement · score 0.13
- coronary artery disease · score 0.12
- Hypercholesterolemia · score 0.12
- uric acid measurement · score 0.11
- platelet crit · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BQK8-F1 | alphafold | PREDICTED | 61.12 | — |
Amino-acid sequence (851 residues)
MNYVGQLAET VFGTVKELYR GLNPATLSGG IDVLVVKQVD GSFRCSPFHV RFGKLGVLRS REKVVDIELN GEPVDLHMKL GDSGEAFFVQ ELESDDEHVP PGLCTSPIPW GGLSGFPSDS QLGTASEPEG LVMAGTASTG RRKRRRRRKP KQKEDAVATD SSPEELEAGA ESELSLPEKL RPEPPGVQLE EKSSLQPKDI YPYSDGEWPP QASLSAGELT SPKSDSELEV RTPEPSPLRA ESHMQWAWGR LPKVARAERP ESSVVLEGRA GATSPPRGGP STPSTSVAGG VDPLGLPIQQ TEAGADLQPD TEDPTLVGPP LHTPETEESK TQSSGDMGLP PASKSWSWAT LEVPVPTGQP ERVSRGKGSP KRSQHLGPSD IYLDDLPSLD SENAALYFPQ SDSGLGARRW SEPSSQKSLR DPNPEHEPEP TLDTVDTIAL SLCGGLADSR DISLEKFNQH SVSYQDLTKN PGLLDDPNLV VKINGKHYNW AVAAPMILSL QAFQKNLPKS TMDKLEREKM PRKGGRWWFS WRRRDFLAEE RSAQKEKTAA KEQQGEKTEV LSSDDDAPDS PVILEIPSLP PSTPPSTPTY KKSLRLSSDQ IRRLNLQEGA NDVVFSVTTQ YQGTCRCKAT IYLWKWDDKV VISDIDGTIT KSDALGHILP QLGKDWTHQG ITSLYHKIQL NGYKFLYCSA RAIGMADLTK GYLQWVSEGG CSLPKGPILL SPSSLFSALH REVIEKKPEV FKVACLSDIQ QLFLPHGQPF YAAFGNRPND VFAYRQVGLP ESRIFTVNPR GELIQELIKN HKSTYERLGE VVELLFPPVA RGPSTDLANP EYSNFCYWRE PLPAVDLDTL D
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