Proteasomal ATPase-associated factor 1 (PAAF1)

About Proteasomal ATPase-associated factor 1

Proteasomal ATPase-associated factor 1 (PAAF1) is a protein from Homo sapiens identified by UniProt accession Q9BRP4, 392 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	Proteasomal ATPase-associated factor 1
UniProt accession	Q9BRP4
Gene	PAAF1
Organism	Homo sapiens
Length	392 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.34
urate measurement · score 0.10
blood protein measurement · score 0.06
insomnia measurement · score 0.02
cortical thickness · score 0.02
brain measurement · score 0.02
cancer · score 0.02
Albinism · score 0.01
albinism · score 0.01
Alzheimer disease · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BRP4-F1	alphafold	PREDICTED	95.87	—

Amino-acid sequence (392 residues)

MAAPLRIQSD WAQALRKDEG EAWLSCHPPG KPSLYGSLTC QGIGLDGIPE VTASEGFTVN EINKKSIHIS CPKENASSKF LAPYTTFSRI HTKSITCLDI SSRGGLGVSS STDGTMKIWQ ASNGELRRVL EGHVFDVNCC RFFPSGLVVL SGGMDAQLKI WSAEDASCVV TFKGHKGGIL DTAIVDRGRN VVSASRDGTA RLWDCGRSAC LGVLADCGSS INGVAVGAAD NSINLGSPEQ MPSEREVGTE AKMLLLARED KKLQCLGLQS RQLVFLFIGS DAFNCCTFLS GFLLLAGTQD GNIYQLDVRS PRAPVQVIHR SGAPVLSLLS VRDGFIASQG DGSCFIVQQD LDYVTELTGA DCDPVYKVAT WEKQIYTCCR DGLVRRYQLS DL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards